Microbiology and immunology current in topics

Research topics under these disciplines includes Autoimmunity, Basic immunological mechanisms, Bacteriology, Cancer immunology, Evolution, Host-pathogen interactions, Immunology of organ transplantation, Innate Immunity, Parasitology, Virology, Disease Pathogenesis, and Development of novel antimicrobial therapies. Sporotrichosis is an emerging deep mycosis and a public health concern in the US and UK et.al. This mycosis is caused by the traumatic inoculation of several species of Sporothrix from nature. However, when cats transmit the disease to humans as zoonotic transmission, severe extracutaneous manifestations are observed.


Therefore, effective control of the disease requires the engagement of host receptors by pathogen-derived molecules to stimulate the immune response. In this context, extracellular vesicles from Sporothrix sp contribute to intracellular communication with host cells. In addition, however, extracellular vesicles may contribute to the spread of this fungus via delivering molecules such as proteins, nucleic acids, and lipids. Thus, understanding mechanisms behind extracellular vesicles related to Sporothrix may provide us with a way to understand and identify its capacity to manipulate the host immune system and spread the infection.

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