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Showing posts from December, 2022

Immunoinformatics & Systems Immunology

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Immunology  exploration tends to a fascinating medium for the preface, understanding and explanation of complex sensible information. Data appears as illuminative mix plates, exceptional exploration papers, councils, medications and theoretical structures. The position of argument reaches to the cell immunology, excrescence immunology,  immunoregulation , immunopathology, supplementary immunology, molecular immunology and autoimmunity have assured and microbial restriction including viral immunology, transplantation immunology, Immunoendocrinology, translational immunology,  Neuroimmunology  and clinical immunology. Antibody Engineering & Technology Proteomics Antigen-Antibody Interactions Microarray Recombinant Immuno-Conjugates Characterization of Lymphocytes Immunodiagnostic & Immuno techniques Transcriptomics               Immunological Assay Nano-Immunotechnology Technology Development and Applications

Epigenetics in Immune-Mediated Disease

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  pigenetics can be defined as the collective modifications in the chemical structure of DNA and histone proteins, without altering the basic DNA nucleotide sequence. This can result in changes in gene expression primarily via regulating chromatin accessibility. Gene expression can also be altered by non-coding RNAs which have been increasingly recognized to be expressed throughout the genome. Understanding epigenetic modifications and the functional implications of individual epigenetic marks has helped to illuminate the complexity of mammalian genomes and has provided important insights into the regulatory role of intergenic and non-protein-coding genomic regions.  In addition, genetic-epigenetic interaction, whereby disease-associated genetic variants directly or indirectly influence locus-specific epigenetic modifications, can provide mechanistic implications for disease-associated genetic variants in immune-mediated diseases.