Epigenetics in Immune-Mediated Disease

 pigenetics can be defined as the collective modifications in the chemical structure of DNA and histone proteins, without altering the basic DNA nucleotide sequence. This can result in changes in gene expression primarily via regulating chromatin accessibility. Gene expression can also be altered by non-coding RNAs which have been increasingly recognized to be expressed throughout the genome. Understanding epigenetic modifications and the functional implications of individual epigenetic marks has helped to illuminate the complexity of mammalian genomes and has provided important insights into the regulatory role of intergenic and non-protein-coding genomic regions. 


In addition, genetic-epigenetic interaction, whereby disease-associated genetic variants directly or indirectly influence locus-specific epigenetic modifications, can provide mechanistic implications for disease-associated genetic variants in immune-mediated diseases.

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