Cutting Edge mTORC2 Regulates CD8 Effector and Memory T Cell Isolation through Serum and Glucocorticoid Kinase 1

The mechanistic target of rapamycin is an essential controller of T cell metabolism and isolation. In this study, we demonstrate that serum- and glucocorticoid- regulated kinase 1( SGK1), a downstream knot of mechanistic target of rapamycin complex 2 signaling, represses memory CD8 T cell isolation. During acute infections, murine SGK1-deficient CD8 T cells borrow an early memory precursor phenotype leading to further long- lived memory T cells.


therefore, SGK1-deficient CD8 T cells demonstrate an enhanced recall capacity in response to reinfection and can readily reject excrescences. Mechanistically, activation of SGK1-deficient CD8 T cells results in dropped Foxo1 phosphorylation and increased nuclear translocation of Foxo1 to promote early memory development. Overall, SGK1 might prove to be a important target for enhancing the efficacity of vaccines and excrescence immunotherapy.

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